File:Syncell whitespace.png

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== Summary ==
DARPA "white space" chart. This chart shows a conceptual trajectory for using synthetic cells to engineering biology at scale. The vertical axis measures the complexity of the system by the number of engineered functional elements (nominally a gene assembly, such as a repressor). The horizontal axis measures the operational lifetime of the systems.

Individual data points:
* [[Adamala2017 - Circuit interactions within and between synthetic cells|Adamala Syn Cell (2017)]]: 6-8 genes, ran for 3-6 hours
* [[Elowitz2000 - Oscillatory network of transcriptional regulators|Represillator (2000)]]: 3 genes, ran for ~10 hours before oscillations died out
* [[Roquet2016 - Recombinase-based state machines|Roquet FSM (2016)]]: 6-input FSM used 8 genes. Ran over 6 days [need to confirm]
* [[Nielsen2016 - Genetic circuit design automation|Cello logic gates (2016)]]: 11 genes in half-adder, ran for 4-8 hours
* Synthetic insulin - 2 peptides in E. coli. Batches run for 24-72 hours
* [[Yim2011 - Metabolic engineering of E. coli for production of 1,4-BDO|Geno 1,4-BDO (2011)]]: 6 genes in E. coli. Batches run for 24-72 hours
* [[Srinivasan2020 - Biosynthesis of medicinal tropane alkaloids in yeast|Srinivasan and Smolke (2020)]]: 26 genes (+ 8 deletions) in yeast for 72 hours
* [[http:en.wikipedia.org/wiki/Tardigrade|Tardigrade]]: lives ~2 months, 11-14K genes
* [[http:en.wikipedia.org/wiki/Carpenter_ant|Carpenter ant]]: 17K genes, lives for a year, 2-6 weeks w/out food

== Licensing ==
{{CC BY-4.0}}

SynCell - Recent changes [en]

File:Syncell whitespace.png