Schmidt Sciences DevCell Project - Revision history

Murray at 16:08, 25 February 2026

2026-02-25T16:08:06Z

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Murray at 16:07, 25 February 2026

2026-02-25T16:07:42Z

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Murray at 16:06, 25 February 2026

2026-02-25T16:06:48Z

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2026-02-25T16:06:08Z

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Murray at 23:35, 1 February 2026

2026-02-01T23:35:44Z

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	The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.		The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.

	* [~~DevCells Kickoff Workshop~~ https://devnotes.nucleus.engineering/articles/bnext-devnotes-devcells-kickoff-workshop]		* [https://devnotes.nucleus.engineering/articles/bnext-devnotes-devcells-kickoff-workshop DevCells Kickoff Workshop]
	* [~~Chicago node demonstration plans~~ https://devnotes.nucleus.engineering/collections-devcell-node-chicago]		* [https://devnotes.nucleus.engineering/collections-devcell-node-chicago Chicago node demonstration plans]
	* [~~London node demonstration plans~~ https://devnotes.nucleus.engineering/collections-devcell-node-london]		* [https://devnotes.nucleus.engineering/collections-devcell-node-london London node demonstration plans]

	=== Upcoming events ===		=== Upcoming events ===

Murray at 23:33, 1 February 2026

2026-02-01T23:33:06Z

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	The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.		The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.

	* [DevCells Kickoff Workshop https://devnotes.nucleus.engineering/articles/bnext-devnotes-devcells-kickoff-workshop)		* [DevCells Kickoff Workshop https://devnotes.nucleus.engineering/articles/bnext-devnotes-devcells-kickoff-workshop]
	* [Chicago node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-chicago]		* [Chicago node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-chicago]
	* [London node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-london]		* [London node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-london]

Murray at 23:32, 1 February 2026

2026-02-01T23:32:41Z

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	[[Image:murray_jhu2025-firstpage.png\|right\|320px\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]		[[Image:murray_jhu2025-firstpage.png\|right\|320px\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]
	The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.		The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.

			* [DevCells Kickoff Workshop https://devnotes.nucleus.engineering/articles/bnext-devnotes-devcells-kickoff-workshop)
			* [Chicago node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-chicago]
			* [London node demonstration plans https://devnotes.nucleus.engineering/collections-devcell-node-london]

	=== Upcoming events ===		=== Upcoming events ===
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	* [https://github.com/biocircuits/bioscrape BioSCRAPE] - Biological stochastic simulation of single cell reactions and parameter estimation		* [https://github.com/biocircuits/bioscrape BioSCRAPE] - Biological stochastic simulation of single cell reactions and parameter estimation
	* [https://www.buildacell.org Build-A-Cell] - Open collaboration supporting the science and engineering of building synthetic cells		* [https://www.buildacell.org Build-A-Cell] - Open collaboration supporting the science and engineering of building synthetic cells
	* [https://nucleus.~~bnext.bio~~ Nucleus] - Open source package for synthetic cell builders		* [https://nucleus.engineering Nucleus] - Open source package for synthetic cell builders
	* [https://github.com/martinez-zacharya/TRILL TRILL] - Sandbox for creative protein engineering and discovery		* [https://github.com/martinez-zacharya/TRILL TRILL] - Sandbox for creative protein engineering and discovery
	* [https://vivarium-collective.github.io Vivarium ] - Simulation engine for composing and executing integrative multi-scale models		* [https://vivarium-collective.github.io Vivarium ] - Simulation engine for composing and executing integrative multi-scale models


	{{Consortium		{{Consortium

Murray: synthetic cells → developer cells

2025-12-15T14:22:37Z

synthetic cells → developer cells

← Older revision		Revision as of 07:22, 15 December 2025
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	[[Image:murray_jhu2025-firstpage.png\|right\|320px\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]		[[Image:murray_jhu2025-firstpage.png\|right\|320px\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]
	The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in ~~synthetic~~ cells, a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. ~~Synthetic~~ cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of ~~synthetic~~ cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.		The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in "developer cells", a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Developer cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of developer cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.

	=== Upcoming events ===		=== Upcoming events ===

Murray at 20:04, 14 November 2025

2025-11-14T20:04:34Z

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	<p>		<p>
	~~Camille~~ Chazot    Neha Kamat    Allen Liu    Julius Lucks    Ryan Truby    Danielle Tullman-Ercek <br>		Cécile Chazot    Neha Kamat    Allen Liu    Julius Lucks    Ryan Truby    Danielle Tullman-Ercek <br>
	Chicago (Northwestern/U. Mich)		Chicago (Northwestern/U. Mich)
	</p>		</p>

Murray at 13:49, 10 November 2025

2025-11-10T13:49:08Z

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	[[Image:murray_jhu2025-firstpage.png\|right\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]		[[Image:murray_jhu2025-firstpage.png\|right\|320px\|link=https://www.cds.caltech.edu/~murray/talks/devcells-jhu_11Nov2025.pdf]]
	The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in synthetic cells, a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Synthetic cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of synthetic cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.		The goal of this project is to demonstrate a model for biological systems engineering that can serve as a starting point for a larger effort in systems engineering of biological systems. We are focused on proof-of-concept demonstrations in synthetic cells, a class of non-living biological machines, constructed from biological components such as lipids, amino acids, proteins, and DNA. Synthetic cells do not mutate or evolve, allowing more systematic and repeatable engineering, and also providing significant advantages in environments where it may not be desirable to deploy genetically engineered organisms. A major element of our work is the development of open source tools that help “routinize” the creation of synthetic cells. We anticipate that the methods we develop can also serve as a testbed for engineering methods in living organisms.